The MOTION Study: Cryoablation for Painful Bone Metastases

One of our main goals was to increase broader adoption and knowledge of this and for pain palliation. It was really a simple prospective single-arm trial. It was international. I think we had four European sites, many out of France, looking at people with painful single bone metastasis and treating with cryoablation. We enrolled very similar to the mass trials in the '60s, like '66 or something like that. We took it out for six months. The primary objective was greater than two-point reduction of the pain score.

Then we looked at opioid use, quality of life, and like I said, carried it out for six months. The big impetus was also to just reinvigorate this more global, broader adoption of it because it's a need. You and I have talked about this multiple times. We just need to get more and more people doing this. Equally, to get the NCCN Guidelines and guidelines to promote this. As you've seen, we talked about this last time. We made a lot of leaps and jumps with it, come to NCCN Guidelines and ablation for pain palliation.