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How to Simplify Dosing: Understanding Y90 Dosimetry from Simple to Complex

with Dr. Sid Padia, Dr. Sabeen Dhand, Dr. Zach Berman, and Dr. Kirema Garcia-Reyes

Of all the topics covered during interventional radiology training, dosimetry education is often delayed until after IRs enter clinical practice. In this episode, Drs. Tyler Sandow and Sabeen Dhand host a roundtable discussion with experts on the dosimetry fundamentals that all Y90 operators should understand. They are joined by interventional radiologists Drs. Zachary Berman, Kirema Garcia-Reyes, and Siddharth Padia, who provide their expert insights.

This podcast is supported by an educational grant from:

AstraZeneca

With additional support from:

Boston Scientific

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How to Simplify Dosing: Understanding Y90 Dosimetry from Simple to Complex with Dr. Sid Padia, Dr. Sabeen Dhand, Dr. Zach Berman, and Dr. Kirema Garcia-Reyes on the BackTable Tumor Board Podcast)

Ep 2 How to Simplify Dosing: Understanding Y90 Dosimetry from Simple to Complex with Dr. Sid Padia, Dr. Sabeen Dhand, Dr. Zach Berman, and Dr. Kirema Garcia-Reyes

00:00 / 01:04

BackTable, LLC (Producer). (2025, January 17). Ep. 2 – How to Simplify Dosing: Understanding Y90 Dosimetry from Simple to Complex [Audio podcast]. Retrieved from https://www.backtable.com

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Podcast Contributors

Dr. Siddharth Padia

Dr. Sid Padia is an interventional radiologist at UCLA in Los Angeles, California.

Dr. Sabeen Dhand

Dr. Sabeen Dhand is a practicing interventional radiologist with PIH Health in Los Angeles.

Dr. Zach Berman

Dr. Zachary Berman is an interventional radiologist at the University of California San Diego in San Diego, California.

Dr. Kirema Garcia-Reyes

Dr. Kirema Garcia-Reyes is an interventional radiologist and assistant professor with Mount Sinai in New York City.

Dr. Tyler Sandow

Dr. Tyler Sandow is an interventional radiologist with Ochsner Health in New Orleans, Louisiana.

Synopsis

The group agrees that dosimetry is not a one-size-fits-all approach. Dosing strategies depend on factors such as tumor size, perfusion territory, underlying liver function, the choice between glass versus resin spheres, and treatment intent. These considerations are illustrated with real-life case examples. The doctors also explore voxel-based dosimetry, a method for calculating the amount of radiation absorbed by different parts of the tumor. They stress the importance of learning how to perform accurate dosage calculations.

Finally, the conversation touches on data from major Y90 trials, current guidelines, and the evolving perspective on Y90 as a potential curative treatment, rather than merely a bridging therapy.

Timestamps

00:00 - Introduction
01:59 - Dosimetry Education During Training
05:46 - Benefit of Individualized Dosing
11:01 - Complications from High Doses
15:19 - Dosage Calculation Cases
22:51 - Duration of Response to Y90
25:00 - Dosing Based on Treatment Intent
29:11 - Challenging Case Example
42:31 - Voxel-Based Dosimetry
45:15 - Using Dosimetry Software

Resources

LEGACY Trial (Salem et al, 2021):
https://pmc.ncbi.nlm.nih.gov/articles/PMC8596669/

Voxel-based tumor dose correlates to complete pathologic necrosis after transarterial radioembolization for hepatocellular carcinoma (Pianka et al, 2024):
https://pubmed.ncbi.nlm.nih.gov/38913189/

RAPY90D Trial (Kappadath et al, 2023):
https://jnm.snmjournals.org/content/64/supplement_1/P268

Clinical, dosimetric, and reporting considerations for Y-90 glass microspheres in hepatocellular carcinoma: updated 2022 recommendations from an international multidisciplinary working group (Salem et al, 2023):
https://pubmed.ncbi.nlm.nih.gov/36114872/

International recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres (Levillain, 2021):
https://link.springer.com/article/10.1007/s00259-020-05163-5)

Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.

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