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BackTable / VI / Podcast / Episode #400
Intra-Arterial Approaches in Brain Tumor Therapy: Overcoming the Blood-Brain Barrier
with Dr. Piotr Walczak and Dr. Prakash Ambady
In this episode of the Backtable Podcast, guest host Dr. Paul Bhogal, a consultant interventional neuroradiologist at Royal London Hospital in the UK, and guests Dr. Piotr Walczak and Dr. Prakash Ambady discuss the potential of intra-arterial treatments combined with blood brain barrier (BBB) manipulation in treating various neurological conditions and tumors.
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BackTable, LLC (Producer). (2024, January 3). Ep. 400 – Intra-Arterial Approaches in Brain Tumor Therapy: Overcoming the Blood-Brain Barrier [Audio podcast]. Retrieved from https://www.backtable.com
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Podcast Contributors
Dr. Piotr Walczak
Dr. Piotr Walczak is a professor in the department of diagnostic radiology and the co-director of image-guided neurointerventions at the University of Maryland in Baltimore.
Dr. Prakash Ambady
Dr. Prakash Ambady is a neuro oncologist in Portland, Oregon.
Dr. Paul Bhogal
Dr. Paul Bhogal is a consultant interventional and diagnostic neuroradiologist and director at B.R.A.I.N. conference.
Synopsis
The trio of doctors discuss methods such as the use of hyperosmolar mannitol and focused ultrasound to breach the BBB and deliver drugs directly to the brain tissue. Dr. Walczak and Dr. Ambady also highlight their individual research areas, including therapies involving cell delivery and engineered cells. The conversation also covers potential risks and new perspectives in comparison to current techniques such as whole-brain radiation.
Timestamps
00:00 - Introduction
05:44 - Challenges of Treating Glioblastoma Multiforme
12:52 - Understanding the Blood Brain Barrier
18:30 - Strategies to Negate the Blood Brain Barrier
20:52 - Blood Brain Barrier Disruption Using Intra-Arterial Mannitol
26:35 - Infusion Rates and Magnetic Resonance Guidance
33:47 - Role of Radiolabel Studies in Drug Delivery
36:31 - Future of Therapeutic Agents Design
47:54 - Potential of Focused Ultrasound in Drug Delivery
56:10 - Exploring the Use of Cells in Drug Delivery
58:44 - Future of Intra-Arterial Interventions
Resources
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma:
https://pubmed.ncbi.nlm.nih.gov/15758009/
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial:
https://pubmed.ncbi.nlm.nih.gov/19269895/
REMOVAL OF RIGHT CEREBRAL HEMISPHERE FOR CERTAIN TUMORS WITH HEMIPLEGIA - PRELIMINARY REPORT:
https://jamanetwork.com/journals/jama/article-abstract/254927
Real-Time MRI Guidance for Reproducible Hyperosmolar Opening of the Blood-Brain Barrier in Mice:
https://www.researchgate.net/publication/328537972_Real-Time_MRI_Guidance_for_Reproducible_Hyperosmolar_Opening_of_the_Blood-Brain_Barrier_in_Mice
Dr. Piotr Walczak ResearchGate Profile:
https://www.researchgate.net/profile/Piotr-Walczak-6
Dr. Prakash Ambday ResearchGate Profile:
https://www.researchgate.net/profile/Prakash-Ambady
Maculopathy Associated With Osmotic Blood- Brain Barrier Disruption and Chemotherapy in Patients With Primary CNS Lymphoma:
https://pubmed.ncbi.nlm.nih.gov/32484895/
PET imaging of intra-arterial 89 Zr bevacizumab in mice with and without osmotic opening of the blood-brain barrier: distinct advantage of intra-arterial delivery:
10.2967/jnumed.118.218792
Safety of intra-arterial chemotherapy with or without osmotic blood–brain barrier disruption for the treatment of patients with brain tumors:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307096/
Delivery of chemotherapeutics across the blood-brain barrier: challenges and advances:
https://pubmed.ncbi.nlm.nih.gov/25307218/
Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.
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