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BackTable / VI / Podcast / Episode #508
Advancements in Pulmonary Embolus Intervention Techniques: PEERLESS Trial Insights
with Dr. Ripal Gandhi and Dr. Zarina Sharalaya
Interventional treatment for pulmonary embolism (PE) has significantly evolved in recent years, largely due to advancements in techniques, knowledge, and device technology. Dr. Zarina Sharalaya (interventional and structural cardiologist) and Dr. Ripal Gandhi (interventional radiologist) join host Dr. Chris Beck to discuss the evolving landscape of PE treatment, comparing large-bore mechanical thrombectomy with catheter-directed thrombolysis and exploring outcomes from the PEERLESS randomized control trial.
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BackTable, LLC (Producer). (2025, January 14). Ep. 508 – Advancements in Pulmonary Embolus Intervention Techniques: PEERLESS Trial Insights [Audio podcast]. Retrieved from https://www.backtable.com
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Podcast Contributors
Dr. Ripal Gandhi
Dr. Ripal Gandhi is an interventional radiologist at Miami Vascular Specialists in Miami, Florida.
Dr. Zarina Sharalaya
Dr. Zarina Sharalya is an interventional cardiologist practicing at North Texas Health Center in Dallas, Texas.
Synopsis
Dr. Sharalaya and Dr. Gandhi begin by covering risk stratification and treatment algorithms for their patients with PE. The doctors then go onto discuss the procedure in detail, and best practices and techniques for mechanical thrombectomy. The conversation also focuses on the PEERLESS trial, highlighting how the study showed significant benefits of mechanical thrombectomy, including faster symptom improvement, decreased ICU stay, and reduced readmission rates. Dr. Sharalaya and Dr. Gandhi conclude the episode with a series of case presentations.
Timestamps
00:00 - Introduction
08:01 - Pulmonary Embolism Risk Stratification and Treatment Algorithms
14:49 - Procedure Overview
24:25 - Best Practices and Techniques in Thrombectomy
34:31 - Peerless Study Overview and Findings
46:50 - Gender Differences in PE Treatment
47:49 - Future of PE Treatment and Advice
51:55 - Case Presentations and Clinical Insights
Resources
2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS):
https://pubmed.ncbi.nlm.nih.gov/31504429/
PEERLESS II: A Randomized Controlled Trial of Large-Bore Thrombectomy Versus Anticoagulation in Intermediate-Risk Pulmonary Embolism:
https://www.jscai.org/article/S2772-9303(24)01053-6/fulltext
Large-bore Mechanical Thrombectomy Versus Catheter-directed Thrombolysis in the Management of Intermediate-risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial:
https://pubmed.ncbi.nlm.nih.gov/39470698/
Disclaimer: The Materials available on BackTable.com are for informational and educational purposes only and are not a substitute for the professional judgment of a healthcare professional in diagnosing and treating patients. The opinions expressed by participants of the BackTable Podcast belong solely to the participants, and do not necessarily reflect the views of BackTable.
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